Elsevier, Biophysical Chemistry, 2-3(136), p. 159-163
DOI: 10.1016/j.bpc.2008.04.009
Full text: Unavailable
AFM imaging and physico-chemical studies provide evidence of the ability of the G-quadruplex structure, formed by a homopurine DNA sequence present in the human telomerase gene promoter, to self-assemble, giving rise to periodical linear superstructures. The reported study suggests the possibility of G-rich DNA sequences to form a new type of G-wire stabilized by end-to-end stacking between terminal G-quartets and characterized by loops of adenine extruded by parallel G-quadruplex repetitive elements. © 2008 Elsevier B.V. All rights reserved.