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Oxford University Press, Nucleic Acids Research, suppl_1(38), p. D552-D556, 2009

DOI: 10.1093/nar/gkp937

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STITCH 2: An interaction network database for small molecules and proteins

Journal article published in 2009 by Michael Kuhn, Damian Szklarczyk, Andrea Franceschini, Monica Campillos, Christian von Mering ORCID, Lars Juhl Jensen ORCID, Andreas Beyer, Peer Bork ORCID,
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Over the last years, the publicly available knowledge on interactions between small molecules and proteins has been steadily increasing. To create a network of interactions, STITCH aims to integrate the data dispersed over the literature and various databases of biological pathways, drug–target relationships and binding affinities. In STITCH 2, the number of relevant interactions is increased by incorporation of BindingDB, PharmGKB and the Comparative Toxicogenomics Database. The resulting network can be explored interactively or used as the basis for large-scale analyses. To facilitate links to other chemical databases, we adopt InChIKeys that allow identification of chemicals with a short, checksum-like string. STITCH 2.0 connects proteins from 630 organisms to over 74 000 different chemicals, including 2200 drugs. STITCH can be accessed at http://stitch.embl.de/.