Published in

Public Library of Science, PLoS ONE, 8(6), p. e24215, 2011

DOI: 10.1371/journal.pone.0024215

Links

Tools

Export citation

Search in Google Scholar

Diabetes is a risk factor for pulmonary tuberculosis: a case-control study from mwanza, Tanzania

Journal article published in 2011 by Daniel Faurholt-Jepsen, Nyagosya Range, George Amani Praygod, Kidola Jeremiah, Maria Faurholt-Jepsen, Martine Grosos Aabye, John Changalucha, Dirk Lund Christensen, Christian Bressen Pipper, Henrik Krarup, Daniel Rinse Witte ORCID, Aase Bengaard Andersen, Henrik Friis
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Diabetes and TB are associated, and diabetes is increasingly common in low-income countries where tuberculosis (TB) is highly endemic. However, the role of diabetes for TB has not been assessed in populations where HIV is prevalent. A case-control study was conducted in an urban population in Tanzania among culture-confirmed pulmonary TB patients and non-TB neighbourhood controls. Participants were tested for diabetes according to WHO guidelines and serum concentrations of acute phase reactants were measured. The association between diabetes and TB, and the role of HIV as an effect modifier, were examined using logistic regression. Since blood glucose levels increase during the acute phase response, we adjusted for elevated serum acute phase reactants. Among 803 cases and 350 controls the mean (SD) age was 34.8 (11.9) and 33.8 (12.0) years, and the prevalence of diabetes was 16.7% (95% CI: 14.2; 19.4) and 9.4% (6.6; 13.0), respectively. Diabetes was associated with TB (OR 2.2, 95% CI: 1.5; 3.4, p