Published in

BioMed Central, Thyroid Research, S1(4), 2011

DOI: 10.1186/1756-6614-4-s1-s3

Links

Tools

Export citation

Search in Google Scholar

Hypothyroidism and mood disorders: integrating novel insights from brain imaging techniques

Journal article published in 2011 by Maximilian Pilhatsch ORCID, Michael Marxen, Christine Winter, Michael N. Smolka ORCID, Michael Bauer
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Abstract Thyroid hormones play a critical role in brain development but also in the adult human brain by modulating metabolic activity. Hypothyroid states are associated with both functional and structural brain alterations also seen in patients with major depression. Recent animal experimental and preclinical data indicate subtle changes in myelination, microvascular density, local neurogenesis, and functional networks. The translational validity of such studies is obviously limited. Clinical evidence for neurobiological correlates of different stages and severities of hypothyroidism and effects of pharmacological intervention is lacking but may be achieved using advanced imaging techniques, e.g. functional and quantitative MRI techniques applied to patients with hypothyroidism before and after hormone replacement therapy.