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American Society for Microbiology, Journal of Virology, 8(88), p. 4595-4599, 2014

DOI: 10.1128/jvi.03190-13

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Novel Avian-Origin Influenza A (H7N9) Virus Attachment to the Respiratory Tract of Five Animal Models

Journal article published in 2014 by Jurre Y. Siegers, Kirsty R. Short, Lonneke M. E. Leijten, Miranda de Graaf, Monique I. J. Spronken, Eefje J. A. Schrauwen, Nicolle Marshall, Anice C. Lowen, Gülsah Gabriel, Albert D. M. E. Osterhaus, Thijs Kuiken, Debby van Riel ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We determined the pattern of attachment of the avian-origin H7N9 influenza viruses A/Anhui/1/2013 and A/Shanghai/1/2013 to the respiratory tract in ferrets, macaques, mice, pigs, and guinea pigs and compared it to that in humans. The H7N9 attachment pattern in macaques, mice, and to a lesser extent pigs and guinea pigs resembled that in humans more closely than the attachment pattern in ferrets. This information contributes to our knowledge of the different animal models for influenza.