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Association between the TCF7L2 rs12255372 (G/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study

Journal article published in 2015 by Dieudonne Nanfa, Eugene Sobngwi, Barbara Atogho-Tiedeu, Jean Jacques N. Noubiap, Olivier Sontsa Donfack, Edith Pascale Mato Mofo, Magellan Guewo-Fokeng, Aurelie Nguimmo Metsadjio, Aurelie Nguimmo Metsadjio, Elvis Ndonwi Ngwa, Elvis Ndonwi Ngwa, Priscille Pokam Fosso, Priscille Pokam Fosso, Eric Djahmeni, Rosine Djokam-Dadjeu and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Abstract Background To study the relationship between the rs12255372 (G/T) polymorphism of the transcription factor 7-like 2 ( TCF7L2 ) and type 2 diabetes mellitus (T2DM) in a Cameroonian population. Methods This case–control study included 60 T2DM patients and 60 healthy normoglycemic controls, all unrelated and of Cameroonian origin, aged above 40 years (range 40–87). The Restriction Fragment Length Polymorphism - Polymerase Chain Reaction (RFLP-PCR) was used for genotyping. Results The T allele frequency was significantly higher in the diabetic group (0.44) than in the control group (0.17). This allele was significantly associated to a greater risk of developing T2DM as compared to the G allele (OR = 3.92, 95% CI 2.04 – 7.67, p