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BioMed Central, Retrovirology, 1(6), 2009

DOI: 10.1186/1742-4690-6-71

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The HBZ gene, a key player in HTLV-1 pathogenesis

Journal article published in 2009 by Masao Matsuoka ORCID, Patrick L. Green
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper ( HBZ ) gene, found to be consistently expressed in ATL, has recently been the subject of intensive research efforts. In this review, we summarize recent findings about HBZ and discuss its roles and functions not only in the virus life cycle, but also in HTLV-1 disease pathogenesis.