Published in

Springer Nature [academic journals on nature.com], Journal of Perinatology, 7(29), p. 527-527, 2009

DOI: 10.1038/jp.2009.48

Springer Nature [academic journals on nature.com], Journal of Perinatology, 2(29), p. 79-88, 2008

DOI: 10.1038/jp.2008.132

Links

Tools

Export citation

Search in Google Scholar

Potential of Immunomodulatory Agents for Prevention and Treatment of Neonatal Sepsis

Journal article published in 2008 by James L. Wynn, Josef Neu, Lyle L. Moldawer, Ofer Levy ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Prevention of neonatal infection-related mortality represents a significant global challenge particularly in the vulnerable premature population. The increased risk of death from sepsis is likely due to the specific immune deficits found in the neonate as compared to the adult. Stimulation of the neonatal immune system to prevent and or treat infection has been attempted in the past largely without success. In this review, we identify some of the known deficits in the neonatal immune system and their clinical impact, summarize previous attempts at immunomodulation and the outcomes of these interventions, and discuss the potential of novel immunomodulatory therapies to improve neonatal sepsis outcome.