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Nature Research, Nature, 7357(475), p. 514-518, 2011

DOI: 10.1038/nature10228

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Control of TH17 cells occurs in the Small Intestine

Journal article published in 2011 by Enric Esplugues, Samuel Huber, Nicola Gagliani ORCID, Anja E. Hauser, Terrence Town, Yisong Y. Wan, William O’Connor, Anthony Rongvaux, Nico Van Rooijen, Ann M. Haberman, Yoichiro Iwakura ORCID, Vijay K. Kuchroo, Jay K. Kolls, Jeffrey A. Bluestone, Kevan C. Herold and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Interleukin (IL)-17-producing T helper cells (TH17) are a recently identified CD4+ T cell subset distinct from T helper type 1 (TH1) and T helper type 2 (TH2) cells1. TH17 cells can drive antigen specific autoimmune diseases and are considered the main population of pathogenic T cells driving experimental autoimmune encephalomyelitis (EAE)2, the mouse model for multiple sclerosis. The factors that are needed for the generation of TH17 cells have been well-characterized3–6. However, where and how the immune system controls TH17 cells in vivo remains unclear.