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BioMed Central, Breast Cancer Research, 3(12), 2010

DOI: 10.1186/bcr2577

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Tumour-associated carbohydrate antigens in breast cancer

Journal article published in 2010 by Aurélie Cazet ORCID, Sylvain Julien, Marie Bobowski, Joy Burchell, Philippe Delannoy
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival. Cellular models have shown the implication of these antigens in cell adhesion, migration, proliferation and tumour growth. The present review summarizes our current knowledge of glycosylation changes (structures, biosynthesis and occurrence) in breast cancer cell lines and primary tumours, and the consequences on disease progression and aggressiveness. The therapeutic strategies attempted to target tumour-associated carbohydrate antigens in breast cancer are also discussed.