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American Chemical Society, Journal of the American Chemical Society, 22(130), p. 6896-6897, 2008

DOI: 10.1021/ja710321g

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Inhibition of HIV Fusion with Multivalent Gold Nanoparticles

Journal article published in 2008 by Mary-Catherine Bowman, T. Eric Ballard, T. Eric Ballard, Christopher J. Ackerson, Daniel L. Feldheim, David M. Margolis ORCID, Christian Melander
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721)-gold nanoparticle conjugates displayed activity comparable to that of TAK-779. This result suggests that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics.