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American Society for Microbiology, Infection and Immunity, 3(71), p. 1584-1586, 2003

DOI: 10.1128/iai.71.3.1584-1586.2003

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Expression of Variant Surface Antigens by Plasmodium falciparum Parasites in the Peripheral Blood of Clinically Immune Pregnant Women Indicates Ongoing Placental Infection

Journal article published in 2003 by Michael F. Ofori, {Michael F} Ofori, Trine Staalsoe, Victoria Bam, Maja Lundquist, Kim P. David, {Kim P} David, Edmund N. L. Browne, {Edmund N. L} Browne, Bartholomew D. Akanmori, {Bartholomew D} Akanmori, Lars Hviid ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA PAM ) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA PAM , making them a convenient source of VSA PAM expressors for PAM vaccine research.