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Frontiers Media, Frontiers in Microbiology, (2)

DOI: 10.3389/fmicb.2011.00012

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Role of the Nlrp3 Inflammasome in Microbial Infection

Journal article published in 2011 by Paras K. Anand, R. K. Subbarao Malireddi ORCID, Thirumala-Devi Kanneganti ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The intracellular Nod-like receptor Nlrp3 has emerged as the most versatile innate immune receptor because of its broad specificity in mediating immune response to a wide range of microbial or danger signals. Nlrp3 mediates assembly of the inflammasome complex in the presence of microbial components leading to the activation of caspase-1 and the processing and release of the pro-inflammatory cytokines IL-1β and IL-18. In this review, we give an update on the recent literature examining the role of Nlrp3 inflammasome in response to fungal, bacterial, and viral infections.