Association for Research in Vision and Ophthalmology, Investigative Ophthalmology & Visual Science, 6(52), p. 3874
DOI: 10.1167/iovs.10-6029
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Et1-dependent Ca2+-signaling was investigated at the cellular level in retinal vascular smooth muscle. ET1 increased Ca2+-sparks and asynchronous phasic Ca2+-oscillations. This “digital,” frequency-modulated signaling was not previously apparent in microfluorometry recordings of average [Ca2+]i.