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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 6(51), p. 2219-2222, 2007

DOI: 10.1128/aac.01382-06

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In Vitro Activities of Miltefosine and Two Novel Antifungal Biscationic Salts against a Panel of 77 Dermatophytes

Journal article published in 2007 by Zhongsheng Tong, Fred Widmer, Tania C. Sorrell, Zofia Guse, Katrina A. Jolliffe ORCID, Catriona Halliday, Ok Cha Lee, Fanrong Kong, Lesley C. Wright, Sharon C. A. Chen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 μg/ml, respectively. MI was more active than ITC ( P < 0.001).