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BioMed Central, Molecular Cancer, 1(13), 2014

DOI: 10.1186/1476-4598-13-124

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microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer

Journal article published in 2014 by Lijing Zhang, Yujuan Dong, Nana Zhu, Ho Tsoi, Zengren Zhao, Chung Wah Wu, Kunning Wang, Shu Zheng, Simon Sm Ng, Francis Kl Chan ORCID, Joseph Jy Sung, Jun Yu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background miR-139-5p was identified to be significantly down-regulated in colon tumor tissues by miRNA array. We aimed to clarify its biological function, molecular mechanisms and direct target gene in colorectal cancer (CRC). Methods The biological function of miR-139-5p was examined by cell growth, cell cycle and apoptosis analysis in vitro and in vivo . miR-139-5p target gene and signaling pathway was identified by luciferase activity assay and western blot. Results miR-139-5p was significantly down-regulated in primary tumor tissues ( P