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Current Protocols in Bioinformatics

DOI: 10.1002/0471250953.bi1321s41

Current Protocols in Bioinformatics

DOI: 10.1002/0471250953.bi1301s10

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Proteomics and the Analysis of Proteomic Data: An Overview of Current Protein-Profiling Technologies

Journal article published in 2005 by Erol E. Gulcicek, Christopher M. Colangelo ORCID, Walter McMurray, Terence Wu, Can Bruce, Kathryn Stone, Hongyu Zhao, Kenneth Williams, Heidi Spratt, Baolin Wu, Alexander Kurosky
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This paper is available in a repository.

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Abstract

Mass spectrometry has become a major tool in the study of proteomes. The analysis of proteolytic peptides and their fragment ions by this technique enables the identification and quantitation of the precursor proteins in a mixture. However, deducing chemical structures and then protein sequences from mass-to-charge ratios is a challenging computational task. Software tools incorporating powerful algorithms and statistical methods improved our ability to process the large quantities of proteomics data. Repositories of spectral data make both data analysis and experimental design more efficient. New approaches in quantitative and statistical proteomics make possible a greater coverage of the proteome, the identification of more post-translational modifications, and a greater sensitivity in the quantitation of targeted proteins. Curr. Protoc. Bioinform. 41:13.21.1-13.21.17. © 2013 by John Wiley & Sons, Inc.