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Elsevier, Atherosclerosis, 1(226), p. 140-145

DOI: 10.1016/j.atherosclerosis.2012.10.035

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Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance

Journal article published in 2013 by Simonetta Bacci, Sabrina Prudente ORCID, Massimiliano Copetti, Belinda Spoto, Stefano Rizza, Roberto Baratta, Natalia Di Pietro ORCID, Eleonora Morini, Rosa Di Paola, Alessandra Testa, Francesca Mallamaci, Giovanni Tripepi, Yuan Zhang, Luana Mercuri, Sara Di Silvestre and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Objective: Insulin resistance (IR) and cardiovascular disease (CVD) share a common soil. We investigated the combined role of single nucleotide polymorphisms (SNPs) affecting insulin signaling (ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on CVD, age at myocardial infarction (MI), in vivo insulin sensitivity and in vitro insulin-stimulated nitric oxide synthase (NOS) activity. Design and setting: 1. We first studied, incident cardiovascular events (a composite endpoint comprising myocardial infarction-MI, stroke and cardiovascular death) in 733 patients (2186 person-years, 175 events). 2. In a replication attempt, age at MI was tested in 331 individuals. 3. OGTT-derived insulin sensitivity index (ISI) was assessed in 829 individuals with fasting glucose