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Mary Ann Liebert, Genetic Testing and Molecular Biomarkers, 6(16), p. 524-530, 2012

DOI: 10.1089/gtmb.2011.0267

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Differentiation of African Components of Ancestry to Stratify Groups in a Case–Control Study of a Brazilian Urban Population

Journal article published in 2012 by Vivian N. Silbiger, Mario H. Hirata, Andre D. Luchessi, Fabiana D. V. Genvigir, Alvaro Cerda, Alice C. Rodrigues, Maria A. V. Willrich, Simone S. Arazi, Egidio L. Dorea, Marcia M. S. Bernik, Andre A. Faludi, Marcelo C. Bertolami, Carla Santos, Ángel Carracedo, Antonio Salas ORCID and other authors.
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This paper is available in a repository.

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Abstract

Background: Balancing the subject composition of case and control groups to create homogenous ancestries between each group is essential for medical association studies. Methods: We explored the applicability of single-tube 34-plex ancestry informative markers (AIM) single nucleotide polymorphisms (SNPs) to estimate the African Component of Ancestry (ACA) to design a future case–control association study of a Brazilian urban sample. Results: One hundred eighty individuals (107 case group; 73 control group) self-described as white, brown-intermediate or black were selected. The proportions of the relative contribution of a variable number of ancestral population components were similar between case and control groups. Moreover, the case and control groups demonstrated similar distributions for ACA 0.50 categories. Notably a high number of outlier values (23 samples) were observed among individuals with ACA