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Elsevier, Clinical Microbiology and Infection, 7(18), p. E254-E258, 2012

DOI: 10.1111/j.1469-0691.2012.03886.x

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Multidrug resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies

Journal article published in 2012 by Maria S. Ramirez, Gary Xie ORCID, Steven H. Marshall, Kristine M. Hujer, Patrick S. G. Chain, Robert A. Bonomo, Marcelo E. Tolmasky ORCID
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This paper is available in a repository.

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Abstract

Comparison of genome-wide, high-resolution restriction maps of Klebsiella pneumoniae clinical isolates, including an NDM-1 producer, and in silico-generated restriction maps of sequenced genomes revealed a highly heterogeneous region we designated the “high heterogeneity zone” (HHZ). The HHZ consists of several regions including a “hot spot” prone to insertions and other rearrangements. The HHZ is a characteristic genomic area that can be used in the identification and tracking of outbreak-causing strains.