Published in
American Society of Hematology, Blood, 25(124), p. 3799-3807, 2014
DOI: 10.1182/blood-2014-04-569392
Links
- ORCID
- American Society of Hematology | PDF
- [eprints.nottingham.ac.uk] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Exploiting the kinetic interplay between GPIbα–VWF binding interfaces to regulate hemostasis and thrombosis
Journal article published in 2014 by
Jianchung Chen,
Hairu Zhou,
Alexander Diacovo,
X. Long Zheng,
Jonas Emsley 
,
Thomas G. Diacovo
,
Thomas G. Diacovo
This paper is made freely available by the publisher.
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Abstract
Key PointsGPIbα–VWF-A1 bond kinetics regulates platelet–VWF interactions and can be altered to correct defects in hemostasis or prevent thrombosis. Targeting a distinct GPIbα−VWF-A1 binding interface may offer a unique therapeutic approach to reducing platelet-driven thrombosis.