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Elsevier, Neurobiology of Aging, (40), p. 120-126, 2016

DOI: 10.1016/j.neurobiolaging.2016.01.007

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Rapid eye movement sleep disruption and sleep fragmentation are associated with increased orexin-A cerebrospinal-fluid levels in mild cognitive impairment due to Alzheimer's disease

Journal article published in 2016 by Claudio Liguori, Marzia Nuccetelli, Francesca Izzi, Giuseppe Sancesario, Andrea Romigi ORCID, Alessandro Martorana, Chiara Amoroso, Sergio Bernardini, Mg Marciani, Nb Mercuri, Fabio Placidi
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The orexin system has been investigated in patients affected by mild cognitive impairment (MCI) due to Alzheimer's disease (AD) by measuring orexin-A concentrations in the cerebrospinal fluid (CSF), and correlated to subjective and objective sleep parameters, quantified by questionnaires and polysomnography, respectively. Twenty drug-naïve patients with MCI due to AD were studied and compared with a population of 26 age and/or sex matched controls, divided into subgroups on the basis of the Pittsburgh Sleep Quality Index (PSQI) score. Increased CSF-orexin levels were detected in patients with MCI due to AD in comparison with controls (p