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BioMed Central, Allergy, Asthma and Clinical Immunology, 1(9), 2013

DOI: 10.1186/1710-1492-9-48

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Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue: a preliminary study

Journal article published in 2013 by Claudina A. Pérez-Novo, Yuan Zhang, Simon Denil, Geert Trooskens, Tim De Meyer, Wim Van Criekinge, Paul Van Cauwenberge, Luo Zhang, Claus Bachert
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Staphylococcal enterotoxins may influence the pro-inflammatory pattern of chronic sinus diseases via epigenetic events. This work intended to investigate the potential of staphylococcal enterotoxin B (SEB) to induce changes in the DNA methylation pattern. Nasal polyp tissue explants were cultured in the presence and absence of SEB; genomic DNA was then isolated and used for whole genome methylation analysis. Results showed that SEB stimulation altered the methylation pattern of gene regions when compared with non stimulated tissue. Data enrichment analysis highlighted two genes: the IKBKB and STAT-5B, both playing a crucial role in T- cell maturation/activation and immune response.