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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(40), p. 234-236, 1996

DOI: 10.1128/aac.40.1.234

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Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.

Journal article published in 1996 by S. Rusconi ORCID, M. Moonis, D. P. Merrill, P. V. Pallai, E. A. Neidhardt, S. K. Singh, K. J. Willis, M. S. Osburne, A. T. Profy, J. C. Jenson, M. S. Hirsch
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.