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National Academy of Sciences, Proceedings of the National Academy of Sciences, 15(110), p. 5756-5758, 2013

DOI: 10.1073/pnas.1302554110

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Probing the relative orientation of molecules bound to DNA through controlled interference using second-harmonic generation

Journal article published in 2013 by Benjamin Doughty, Yi Rao, Samuel W. Kazer ORCID, Sheldon J. J. Kwok, Nicholas J. Turro, Kenneth B. Eisenthal
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A method is described in which the interference of radiated second-harmonic electric fields generated by a pair of oriented molecules intercalated into double-stranded DNA is controlled and measured. The results show that the relative molecular orientation of the two molecules significantly changes the magnitude of the observed second-harmonic generation intensity, which is described by a simple model that accounts for the interferences of the radiated fields. The technique presented shows promise for future experiments investigating structural changes induced by the formation of a DNA–biomolecule complex.