Oxford University Press (OUP), Bioinformatics, 19(28), p. 2484-2492
DOI: 10.1093/bioinformatics/bts438
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Motivation: Meta-analysis of genomics data seeks to identify genes associated with a biological phenotype across multiple datasets; however, merging data from different platforms by their features (genes) is challenging. Meta-analysis using functionally or biologically characterized gene sets simplifies data integration is biologically intuitive and is seen as having great potential, but is an emerging field with few established statistical methods.