Published in

Elsevier, Leukemia Research, 8(36), p. e178-e181, 2012

DOI: 10.1016/j.leukres.2012.04.015

Links

Tools

Export citation

Search in Google Scholar

PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia

Journal article published in 2012 by Dagmar Denk, Karin Nebral, Jutta Bradtke, Gertrud Pass, Anja Möricke, Andishe Attarbaschi, Sabine Strehl ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

PAX5 rearrangements resulting in the expression of fusion transcripts account for 2–3% of childhood B-cell precursor acute lymphoblastic leukemia. Most PAX5 fusions are rare and many of them have only been described in a couple of, or even only in single, cases. We have identified the third case with a PAX5-AUTS2 fusion, which results from unbalanced t(7;9)(q11.2;p13.2) rearrangements. Our findings substantiate that PAX5-AUTS2 is a recurrent fusion gene in pediatric B-cell precursor acute lymphoblastic leukemia, and we summarize the clinical characteristics of such patients.