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BioMed Central, Respiratory Research, 1(10), 2009

DOI: 10.1186/1465-9921-10-29

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Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease

Journal article published in 2009 by Joanna L. Richens ORCID, Richard A. Urbanowicz ORCID, Elizabeth Am M. Lunt, Rebecca Metcalf, Jonathan Corne, Lucy Fairclough, Paul O'Shea
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Chronic obstructive pulmonary disease (COPD) is a treatable and preventable disease state, characterised by progressive airflow limitation that is not fully reversible. Although COPD is primarily a disease of the lungs there is now an appreciation that many of the manifestations of disease are outside the lung, leading to the notion that COPD is a systemic disease. Currently, diagnosis of COPD relies on largely descriptive measures to enable classification, such as symptoms and lung function. Here the limitations of existing diagnostic strategies of COPD are discussed and systems biology approaches to diagnosis that build upon current molecular knowledge of the disease are described. These approaches rely on new 'label-free' sensing technologies, such as high-throughput surface plasmon resonance (SPR), that we also describe.