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Oxford University Press (OUP), Carcinogenesis: Integrative Cancer Research, 2(29), p. 333-341

DOI: 10.1093/carcin/bgm284

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Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population

Journal article published in 2008 by Kristy E. Driver, Honglin Song, Fabienne Lesueur, Shahana Ahmed, Nuno L. Barbosa-Morais ORCID, Jonathan P. Tyrer, Bruce A. J. Ponder, Douglas F. Easton, Paul D. P. Pharoah, Alison M. Dunning ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Using a large-scale case–control study, we examined whether common single-nucleotide polymorphisms (SNPs) within 13 genes involved in the cell cycle pathway are associated with breast cancer risk. Seventy-nine tag SNPs were used to evaluate 240 common SNPs found in the genes: CCND1, CCND2, CCND3, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKNIB, CDKN2A/CDKN2B, CDKN2C and CDKN2D. These were genotyped in 2270 cases and 2280 controls from the Studies in Epidemiology and Risks of Cancer Heredity (SEARCH) study. Tag SNPs showing evidence of statistically significant differences between cases and controls (P