<b><i>Background:</i></b> Psoriasis is one of the most common inflammatory skin disorders. There are only limited data on systemic treatment in children. <b><i>Objective:</i></b> To assess the safety and clinical efficacy of the treatment of six paediatric patients with fumaric acid esters (FAE, Fumaderm®) for psoriasis. <b><i>Methods:</i></b> Six patients aged 6-17 years were treated with FAE. Patients underwent regular assessment. Treatment efficacy was evaluated using the Psoriasis Area and Severity Index (PASI) and body surface area (BSA). <b><i>Results:</i></b> The mean duration of treatment was 17.8 months. PASI and BSA were determined after 12 weeks. All patients showed improvement in their skin condition, two achieving PASI75, one PASI90 and three PASI100 response. Proteinuria was encountered in one patient and two patients suffered from gastrointestinal discomfort. Treatment was discontinued due to remission in two patients. <b><i>Conclusion:</i></b> Treatment with FAE in paediatric patients is a valuable alternative option when systemic treatment is needed.