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Karger Publishers, Dementia and Geriatric Cognitive Disorders, 1-2(38), p. 10-15, 2014

DOI: 10.1159/000357126

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DNA Methylation of the TNF-a Promoter Region in Peripheral Blood Monocytes and the Cortex of Human Alzheimer's Disease Patients

Journal article published in 2014 by Oliver Kaut, Alfredo Ramirez ORCID, Heike Pieper, Ina Schmitt, Frank Jessen, Ullrich Wüllner
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

<b><i>Background:</i></b> The cytokine tumor necrosis factor-alpha (TNF-α) is elevated in the blood of Alzheimer's disease (AD) patients. Epigenetic DNA modifications of the TNF-α promoter may account for the observed upregulation. <b><i>Methods:</i></b> We analyzed blood samples of 50 AD patients and 55 controls plus 4 AD and 4 control cortex samples using bisulfite sequencing PCR. <b><i>Results:</i></b> A significant hypomethylation of the TNF-α promoter was found in AD patients' brains but not in their blood. Cortical TNF-α promoter DNA was higher methylated than blood-derived DNA, both in AD patients and controls. <b><i>Conclusion:</i></b> In AD patients, epigenetic mechanisms of TNF-α gene regulation, like aberrant DNA methylation, are not relevant in blood.