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Humana Press, Methods in Molecular Biology, p. 15-30, 2012

DOI: 10.1007/978-1-61779-797-2_2

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The Use of Fluorescent Proteins for Intravital Imaging of Cancer Cell Invasion

Journal article published in 2012 by James Hulit, Dmitriy Kedrin, Bojana Gligorijevic ORCID, David Entenberg ORCID, Jeffrey Wyckoff, John Condeelis, Jeffrey E. Segall, Kedrin D Gligorijevic B Entenberg D Wyckoff J Condeelis J Segall J.-E. Hulit J.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The analysis of cancer cell behavior in the primary tumor in living animals provides an opportunity to explore the process of invasion and intravasation in the complex microenvironment that is present in vivo. In this chapter, we describe the methods that we have developed for performing intravital imaging of mammary tumors. We provide procedures for generating tumors through injection of tumor cell lines, and multiphoton imaging using a skin-flap tumor dissection and a mammary imaging window.