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Elsevier, Vaccine, 5(32), p. 631-638, 2014

DOI: 10.1016/j.vaccine.2013.08.102

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Genetic basis of antigenic variation in foot-and-mouth disease serotype A viruses from the Middle East☆

Journal article published in 2014 by Sasmita Upadhyaya, Gelagay Ayelet, Guntram Paul, Donald P. King, David J. Paton, Mana Mahapatra ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

•The recent A-Iran-05 viruses circulating in middle East do not match with the existing vaccine strains.•We have generated full capsid sequence of 51 A-Iran-05 viruses and their corresponding antigenic (serological) relationship (r1) values using antisera raised against A22 and A/TUR/2006 vaccine.•Analysis of the data to correlate genotype to antigenic phenotype revealed amino acid changes in neutralising antigenic sites.