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Optica, Optics Express, 7(19), p. 6623, 2011

DOI: 10.1364/oe.19.006623

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In vivo three-dimensional optical coherence elastography◊

Journal article published in 2011 by Brendan F. Kennedy, Xing Liang, Steven G. Adie, Bryden C. Quirk, Derek K. Gerstmann, David D. Sampson ORCID, Stephen A. Boppart
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum in the hydrated case.