Published in
American Association for the Advancement of Science, Science Translational Medicine, 261(6), 2014
DOI: 10.1126/scitranslmed.3009318
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- American Association for the Advancement of Science
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
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Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin
Journal article published in 2014 by
Ashley M. Laughney,
Eunha Kim,
Melissa M. Sprachman,
Miles A. Miller,
Rainer H. Kohler,
Katy S. Yang,
James D. Orth,
Timothy J. Mitchison,
Ralph Weissleder 
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Abstract
Single-cell pharmacokinetic analysis of a fluorescent eribulin derivative in vivo revealed drug resistance mediated by MDR1-driven efflux, which was overcome by a nanoencapsulated MDR1 inhibitor.