Published in

Association for Research in Vision and Ophthalmology, Investigative Ophthalmology & Visual Science, 9(55), p. 5551

DOI: 10.1167/iovs.14-14580

Links

Tools

Export citation

Search in Google Scholar

Decreased DJ-1 Leads to Impaired Nrf2-Regulated Antioxidant Defense and Increased UV-A–Induced Apoptosis in Corneal Endothelial Cells

Journal article published in 2014 by Cailing Liu, Yuming Chen, Irene E. Kochevar, Ula V. Jurkunas ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Downregulation of DJ-1 impairs nuclear translocation of Nrf2 causing decreased antioxidant gene expression and increased oxidative damage. Decline in DJ-1 levels leads to heightened corneal endothelial cell susceptibility to UV-A light by activating p53-dependent apoptosis.