Published in
Wiley, ChemMedChem, 9(3), p. 1311-1315, 2008
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- [www.ncbi.nlm.nih.gov] | PDF
- [nrs.harvard.edu] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [dash.harvard.edu] | PDF
- [europepmc.org] | PDF
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Superparamagnetic Iron Oxide Nanoparticle–Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy
Journal article published in 2008 by
Andrew Z. Wang,
Vaishali Bagalkot,
Christophoros C. Vasilliou,
Frank Gu 
,
Frank Alexis,
Liangfang Zhang,
Mariam Shaikh,
Kai Yuet,
Michael J. Cima,
Robert S. Langer,
Philip Wayne Kantoff,
Neil H. Bander,
Sangyong Jon,
Omid Cameron Farokhzad
,
Frank Alexis,
Liangfang Zhang,
Mariam Shaikh,
Kai Yuet,
Michael J. Cima,
Robert S. Langer,
Philip Wayne Kantoff,
Neil H. Bander,
Sangyong Jon,
Omid Cameron Farokhzad
This paper is available in a repository.
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Abstract
(Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.