Cost-effectiveness of fibronectin testing in a triage in women with threatened preterm labor: alleviation of pregnancy outcome by suspending tocolysis in early labor (APOSTEL-I trial)

Vis, Jolande Y.; Wilms, Femke F.; Oudijk, Martijn A.; Porath, Martina M.; Scheepers, Hubertina Cj J.; Bloemenkamp, Kitty Wm M.; Bolte, Annemiek C.; Cornette, Jérôme; Derks, Jan B.; Duvekot, Johannes J.; van Eyck, Jim; Eyck, J. van; Kwee, Anneke; Opmeer, Brent C.; van Pampus, Maria G.; Pampus, M. G. van; Lotgering, Fred K.; Scherjon, Sicco A.; Sollie, Krystyna M.; Spaanderman, Marc Ea A.; Willekes, Christine; van der Post, Joris Am M.; Post, J. A. van der; Mol, Ben Willem J.

Published in

BioMed Central, BMC Pregnancy and Childbirth, 1(9), 2009

DOI: 10.1186/1471-2393-9-38

Tools

Export citation

Search in Google Scholar

Cost-effectiveness of fibronectin testing in a triage in women with threatened preterm labor: alleviation of pregnancy outcome by suspending tocolysis in early labor (APOSTEL-I trial)

Journal article published in 2009 by Jolande Y. Vis, Femke F. Wilms, Martijn A. Oudijk

, Martina M. Porath, Hubertina Cj J. Scheepers, Kitty Wm M. Bloemenkamp, Annemiek C. Bolte, Jérôme Cornette, Jan B. Derks, Johannes J. Duvekot, Jim van Eyck, J. van Eyck, Anneke Kwee, Brent C. Opmeer, Maria G. van Pampus and other authors.

This paper is made freely available by the publisher.

Full text: Download

Preprint: archiving allowed

Upload

Postprint: archiving allowed

Upload

Published version: archiving allowed

Upload

Policy details

Data provided by

Abstract

BACKGROUND: At present, women with threatened preterm labor before 32 weeks of gestation are, after transfer to a perinatal center, treated with tocolytics and corticosteroids. Many of these women are treated unnecessarily. Fibronectin is an accurate predictor for the occurrence of preterm birth among women with threatened preterm labor. We will assess whether triage of these women with fibronectin testing, cervical length or their combination is cost-effective. METHODS/DESIGN: We will investigate a prospective cohort of women referred to a perinatal centre for spontaneous threatened preterm labor between 24 and 34 weeks with intact membranes. All women will be tested for fibronectin and cervical length. Women with a cervical length 30 mm will be managed according to local protocol. Corticosteroids may be given to all women at the discretion of the attending physician. Primary outcome measure will be delivery within 7 days. Secondary outcome measures will be neonatal morbidity and mortality, complications of tocolytics, costs and health related quality of life. The analysis will be according to the intention to treat principle. We anticipate the probability on preterm birth within 7 days in the group of women with a negative fibronectine test to be 5%. Two groups of 110 women will be needed to assure that in case of non-inferiority the difference in the proportion of preterm deliveries

Published in

Links

Tools

Cost-effectiveness of fibronectin testing in a triage in women with threatened preterm labor: alleviation of pregnancy outcome by suspending tocolysis in early labor (APOSTEL-I trial)

Abstract