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SpringerOpen, Nanoscale Research Letters, 1(9), 2014

DOI: 10.1186/1556-276x-9-317

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Synthesis of mixed-sequence oligonucleotides on mesoporous silicon: chemical strategies and material stability

Journal article published in 2014 by Monica Terracciano, Ilaria Rea ORCID, Luca De Stefano, Luca De Stefano ORCID, Ivo Rendina, Giorgia Oliviero, Fabrizia Nici, Stefano D. 'errico, Stefano D'Errico, Gennaro Piccialli, Nicola Borbone
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Rapid screening tests in medical diagnostic and environmental analysis are often based on oligonucleotide biochips. In this paper, we studied the stability of functionalized mesoporous silicon supports in the solid-phase synthesis of oligonucleotides, exploiting several chemical procedures. A 19-mer mixed sequence has been successfully synthesized on aminosilane-modified porous silicon photonic structures. The process and the materials have been characterized by optical reflectivity, atomic force microscopy and high-performance liquid chromatography.