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Oxford University Press (OUP), Rheumatology, 4(53), p. 611-620

DOI: 10.1093/rheumatology/ket401

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CX3CL1 and CX3CR1 expression in tertiary lymphoid structures in salivary gland infiltrates: fractalkine contribution to lymphoid neogenesis in Sjogren's syndrome

Journal article published in 2013 by Elisa Astorri, Rossana Scrivo, M. Bombardieri ORCID, Giovanna Picarelli, Irene Pecorella, Alessandra Porzia, Guido Valesini, R. Priori ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Methods. We assessed the presence of CX3CL1 protein in sera by ELISA in 21 patients with primary SS, 11 patients with Sicca syndrome (Sicca), 20 RA patients and 10 blood donors. Histological evaluation was performed on sequential sections of salivary gland tissue. Using TaqMan RT-PCR we studied CX3CL1 and CX3CR1 mRNA expression in salivary gland tissues from a molecular point of view. Results. Increased serum levels of CX3CL1 protein were observed in SS patients compared with controls (P