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Taylor and Francis Group, Cell Cycle, 11(13), p. 1749-1755, 2014

DOI: 10.4161/cc.28653

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Promyelocytic leukemia bodies tether to early endosomes during mitosis

Journal article published in 2014 by Vuk Palibrk, Emma Lång ORCID, Anna Lång ORCID, Kay Oliver Schink, Alexander D. Rowe, Stig Ove Bøe
This paper is available in a repository.
This paper is available in a repository.

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Abstract

During mitosis the nuclear envelope breaks down, leading to potential interactions between cytoplasmic and nuclear components. PML bodies are nuclear structures with tumor suppressor and antiviral functions. Early endosomes, on the other hand, are cytoplasmic vesicles involved in transport and growth factor signaling. Here we demonstrate that PML bodies form stable interactions with early endosomes immediately following entry into mitosis. The 2 compartments remain stably associated throughout mitosis and dissociate in the cytoplasm of newly divided daughter cells. We also show that a minor subset of PML bodies becomes anchored to the mitotic spindle poles during cell division. The study demonstrates a stable mitosis-specific interaction between a cytoplasmic and a nuclear compartment.