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Elsevier, NeuroImage: Clinical, (8), p. 224-229, 2015

DOI: 10.1016/j.nicl.2015.04.012

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Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures

Journal article published in 2015 by N. Promjunyakul, D. Lahna, J. A. Kaye, H. H. Dodge, D. Erten-Lyons, W. D. Rooney, L. C. Silbert ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

•We examined cerebral blood flow (CBF) surrounding white matter hyperintensity (WMH) lesions.•We examined whether low baseline CBF is associated with WMH expansion over time.•WMH CBF penumbra exists, extending ~12 mm from both periventricular and deep WMH lesions.•Baseline CBF can predict the development of new WMHs over time.•ASL MRI can be used to monitor interventions to increase white matter blood flow.