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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(58), p. 4238-4241, 2014

DOI: 10.1128/aac.00129-14

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Inhibition of Aminoglycoside 6′-N-Acetyltransferase Type Ib by Zinc: Reversal of Amikacin Resistance in Acinetobacter baumannii and Escherichia coli by a Zinc Ionophore

Journal article published in 2014 by David L. Lin, Tung Tran, Jamal Y. Alam, Steven R. Herron, Maria Soledad Ramirez, Marcelo E. Tolmasky ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT In vitro activity of the aminoglycoside 6′- N -acetyltransferase type Ib [AAC(6′)-Ib] was inhibited by ZnCl 2 with a 50% inhibitory concentration (IC 50 ) of 15 μM. Growth of Acinetobacter baumannii or Escherichia coli harboring aac ( 6 ′)- Ib in cultures containing 8 μg/ml amikacin was significantly inhibited by the addition of 2 μM Zn 2+ in complex with the ionophore pyrithione (ZnPT).