Dissemin is shutting down on January 1st, 2025

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BioMed Central, Journal of Negative Results in BioMedicine, 1(13), 2014

DOI: 10.1186/1477-5751-13-12

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Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population

Journal article published in 2014 by Francesca Megiorni ORCID, Serena Resta, Deliar Yazdanian, Deliar Yazdanian Masouleh, Gabriele Cavaggioni, Claudia Lia, Pierluigi Benedetti Panici, Pierluigi Benedetti Panici, Antonio Pizzuti, Maria Grazia Porpora ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population. Findings. A case-control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls. Conclusions: Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients. © 2014 Megiorni et al.; licensee BioMed Central Ltd.