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BioMed Central, Genome Medicine, 3(3), p. 17

DOI: 10.1186/gm231

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Towards an understanding of genetic predisposition to migraine

Journal article published in 2011 by Verneri Anttila ORCID, Maija Wessman, Mikko Kallela, Aarno Palotie
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Plausible genome-wide associations for episodic neurological diseases (such as migraine, epilepsy and ataxias) have been slow to emerge. The first such association was reported in a recent genome-wide association study of migraine, with quantitative expression analysis linking the variant to a nearby regulatory gene, MTDH/AEG-1. This putative mechanism, regulating the expression of the primary glutamate transporter in the brain, EAAT2/GLT-1, has interesting implications bridging the gap between Mendelian and common forms in this key group of disorders.