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Taylor and Francis Group, OncoImmunology, 5(5), p. e1123370, 2016

DOI: 10.1080/2162402x.2015.1123370

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Reducing prostaglandin E<sub>2</sub>production to raise cancer immunogenicity

Journal article published in 2016 by Santiago Zelenay ORCID, Caetano Reis e. Sousa
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cyclooxygenases (COX), commonly upregulated in numerous cancers, generate prostaglandin E2 (PGE2), which has been implicated in key aspects of malignant growth including proliferation, invasion and angiogenesis. Recently, we showed that production of PGE2 by cancer cells dominantly enables progressive tumor growth via immune escape and that cyclooxygenase inhibitors synergize with immunotherapy to enhance tumor eradication.