Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Genetics, 7(46), p. 736-741, 2014

DOI: 10.1038/ng.3002

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Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Journal article published in 2014 by Yufei Wang, James D. Mckay, Thorunn Rafnar, Zhaoming Wang, Maria N. Timofeeva, Peter Broderick ORCID, Xuchen Zong, Marina Laplana ORCID, Yongyue Wei, Younghun Han, Amy Lloyd, Manon Delahaye-Sourdeix, Daniel Chubb, Valerie Gaborieau, William Wheeler and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Research Support, Non-U.S. Gov't ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and 38,295 controls for follow-up. We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)). We also showed an association between common variation at 3q28 (TP63, rs13314271, OR = 1.13, P = 7.22 × 10(-10)) and lung adenocarcinoma that had been previously reported only in Asians. These findings provide further evidence for inherited genetic susceptibility to lung cancer and its biological basis. Additionally, our analysis demonstrates that imputation can identify rare disease-causing variants with substantive effects on cancer risk from preexisting genome-wide association study data.