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American Society for Microbiology, Journal of Bacteriology, 11(185), p. 3476-3479, 2003

DOI: 10.1128/jb.185.11.3476-3479.2003

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The Glycosyltransferase Gene Encoding the Enzyme Catalyzing the First Step of Mycothiol Biosynthesis (mshA)

Journal article published in 2003 by Gerald L. Newton, Teresa Koledin, Batia Gorovitz, Mamta Rawat, Robert C. Fahey, Yossef Av-Gay ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1 d - myo -inosityl 2-acetamido-2-deoxy-α- d -glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacterium smegmatis shown to be GlcNAc-Ins and mycothiol deficient was sequenced to identify a putative glycosyltransferase gene designated mshA . The ortholog in Mycobacterium tuberculosis , Rv0486, was used to complement the mutant phenotype.