Dissemin is shutting down on January 1st, 2025

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BMJ Publishing Group, BMJ, 7565(333), p. 420-0, 2006

DOI: 10.1136/bmj.38902.605347.7c

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Meta-analysis of frusemide to prevent or treat acute renal failure

Journal article published in 2006 by Kwok M. Ho ORCID, David J. Sheridan
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Objective: To investigate the potential beneficial and adverse effects of frusemide to prevent or treat acute renal failure in adults. Design: Meta-analysis of randomised controlled trials. Data sources: Cochrane controlled trials register (2005 issue 4), Embase, and Medline (1966 to 1 February 2006), without language restrictions. Review methods: Two reviewers checked the quality of the studies and independently extracted data. Results: Nine randomised controlled trials totalling 849 patients with or at risk of acute renal failure were included. Outcome measures not significantly different after frusemide treatment were in-hospital mortality (relative risk 1.11, 95% confidence interval 0.92 to 1.33), risk for requiring renal replacement therapy or dialysis (0.99, 0.80 to 1.22), number of dialysis sessions required (weight mean difference - 0.48 sessions, - 1.45 to 0.50), and proportion of patients with persistent oliguria (urine output