Published in
Public Library of Science, PLoS ONE, 11(6), p. e27617, 2011
DOI: 10.1371/journal.pone.0027617
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Coordinated Defects in Hepatic Long Chain Fatty Acid Metabolism and Triglyceride Accumulation Contribute to Insulin Resistance in Non-Human Primates
Journal article published in 2011 by
Subhash Kamath,
Alberto O. Chavez,
Amalia Gastaldelli 
,
Francesca Casiraghi,
Glenn A. Halff,
Gregory A. Abrahamian,
Alberto M. Davalli,
Raul A. Bastarrachea,
Anthony G. Comuzzie,
Rodolfo Guardado-Mendoza ,
Lilia M. Jimenez-Ceja,
Vicki Mattern,
Ana Maria Paez,
Andrea Ricotti,
Mary E. Tejero
and other authors.
,
Francesca Casiraghi,
Glenn A. Halff,
Gregory A. Abrahamian,
Alberto M. Davalli,
Raul A. Bastarrachea,
Anthony G. Comuzzie,
Rodolfo Guardado-Mendoza ,
Lilia M. Jimenez-Ceja,
Vicki Mattern,
Ana Maria Paez,
Andrea Ricotti,
Mary E. Tejero
and other authors.
This paper is made freely available by the publisher.
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Abstract
Non-Alcoholic fatty liver disease (NAFLD) is characterized by accumulation of triglycerides (TG) in hepatocytes, which may also trigger cirrhosis. The mechanisms of NAFLD are not fully understood, but insulin resistance has been proposed as a key determinant.